Human Glycophorin-A/GYPA/CD235a protein (Recombinant) (C-hFC) (STJP002451)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human Glycophorin-A Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser20-Glu91) of human Glycophorin-A (Accession #NP_002090.4) fused with a hFc tag at the C-terminus.
General Information
| Short Description | Recombinant-Human Glycophorin-A/GYPA/CD235a-C-hFC protein was developed in hek293 cells using the region Ser20-Glu91. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Anti-GPA Antibody immobilized on CM5 Chip can bind Human GPA, hFc Tag with an affinity constant of 0.72 Mu M as determined in SPR assay (Biacore T200). |
| Determination Method | <0.01 EU/Mu g |
Target Information
| Gene Symbol | GYPA |
| Gene ID | 2993 |
| Uniprot ID | GLPA_HUMAN |
| Immunogen | Recombinant Human Glycophorin-A Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser20-Glu91) of human Glycophorin-A (Accession #NP_002090.4) fused with a hFc tag at the C-terminus. |
| Immunogen Region | Ser20-Glu91 |
| Immunogen Sequence | SSTTGVAMHTSTSSSVTKSY ISSQTNDTHKRDTYAATPRA HEVSEISVRTVYPPEEETGE RVQLAHHFSEPE |
Additional Info
| Function | Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane. Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. (Microbial infection) Appears to be a receptor for Hepatitis A virus (HAV). (Microbial infection) Receptor for P.falciparum erythrocyte-binding antigen 175 (EBA-175).binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. |
| Protein Name | Glycophorin-AMn SialoglycoproteinPas-2Sialoglycoprotein AlphaCd Antigen Cd235a |
| Database Links | Reactome: R-HSA-202733 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinAppears To Be Colocalized With Slc4a1 |
| Alternative Protein Names | Glycophorin-A proteinMn SialoglycoproteinPas-2 proteinSialoglycoprotein Alpha proteinCd Antigen Cd235a proteinGYPA proteinGPA proteinMNS protein |
Information sourced from Uniprot.org