Human Glutathione Reductase protein (Recombinant) (His-Tag) (STJP017442)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Glutathione Reductase-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | Enzyme Activity/SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% Glycerol, 0.1M NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Specific activity is > 45unit/mg. The unit definition for glutathione reductase activity may be expressed in terms of the oxidation of NADPH or the reduction of GSSG since their molar ratio is 1:1. One unit of glutathione reductase oxidizes 1 umol of |
Target Information
| Gene Symbol | GSR |
| Gene ID | 2936 |
| Uniprot ID | GSHR_HUMAN |
| Accession Number | NP_000628 |
| Immunogen | Human |
| Immunogen Region | 43-522aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSMAMACRQ EPQPQGPPPA AGAVASYDYL VIGGGSGGLA SARRAAELGA RAAVVESHKL GGTCVNVGCV PKKVMWNTAV HSEFMHDHAD YGFPSCEGKF NWRVIKEKRD AYVSRLNAIY QNNLTKSHIE IIRGHAAFTS DPKPTIEVSG KKYTAPHILI ATGGMPSTPH ESQIPGASLG ITSDGFFQLE ELPGRSVIVG AGYIAVEM |
Additional Info
| Function | Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol. |
| Protein Name | Glutathione Reductase - MitochondrialGrGrase |
| Database Links | Reactome: R-HSA-2408550 P00390-2Reactome: R-HSA-3299685Reactome: R-HSA-499943 P00390-2Reactome: R-HSA-5628897 P00390-2Reactome: R-HSA-9818027 P00390-2 |
| Cellular Localisation | Isoform Mitochondrial: MitochondrionIsoform Cytoplasmic: Cytoplasm |
| Alternative Protein Names | Glutathione Reductase - Mitochondrial proteinGr proteinGrase proteinGSR proteinGLUR proteinGRD1 protein |
Information sourced from Uniprot.org