Human GLTPD1 protein (Recombinant) (His-Tag) (STJP018925)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human GLTPD1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) containing 50% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CPTP |
| Gene ID | 80772 |
| Uniprot ID | CPTP_HUMAN |
| Accession Number | NP_001025056 |
| Immunogen | Human |
| Immunogen Region | 1-214aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Ubiquitous. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. |
| Function | Mediates the intracellular transfer of ceramide-1-phosphate (C1P) between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24:0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and the release of arachidonic acid. Has no activity with galactosylceramide, lactosylceramide, sphingomyelin, phosphatidylcholine, phosphatidic acid and ceramide. C1P transfer is stimulated by phosphatidylserine in C1P source vesicles. Regulates autophagy, inflammasome mediated IL1B and IL18 processing, and pyroptosis, but not apoptosis. |
| Protein Name | Ceramide-1-Phosphate Transfer ProteinCptpGlycolipid Transfer Protein Domain-Containing Protein 1Gltp Domain-Containing Protein 1 |
| Database Links | Reactome: R-HSA-9845576 |
| Cellular Localisation | CytoplasmCytosolGolgi ApparatusTrans-Golgi Network MembranePeripheral Membrane ProteinCell MembraneCytoplasmic SideEndosome MembraneNucleus Outer Membrane |
| Alternative Protein Names | Ceramide-1-Phosphate Transfer Protein proteinCptp proteinGlycolipid Transfer Protein Domain-Containing Protein 1 proteinGltp Domain-Containing Protein 1 proteinCPTP proteinGLTPD1 protein |
Information sourced from Uniprot.org