Human GFR alpha-1 protein (Recombinant) (hIgG-Tag) (STJP019564)
SPECIFICATIONS
HostHEK293 Cells
ImmunogenHuman
General Information
| Short Description | Recombinant-Human GFR alpha-1-hIgG-Tag protein was developed from hek293 cells and has a target region of hIgG-Tag. For use in research applications. |
| Applications | SDS-PAGE/Bioactivity |
| Host | HEK293 Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Endotoxin | < 1 EU per 1ug of protein (determined by LAL method) |
| Immunoreactivity | Measured by its binding ability in a functional ELISA with Human GDNF. The ED50 range ≤ 50 ng/ml. |
Target Information
| Gene Symbol | GFRA1 |
| Gene ID | 2674 |
| Uniprot ID | GFRA1_HUMAN |
| Accession Number | NP_665736.1 |
| Immunogen | Human |
| Immunogen Region | 25-424aa |
| Immunogen Sequence | DRLDCVKASD QCLKEQSCST KYRTLRQCVA GKETNFSLAS GLEAKDECRS AMEALKQKSL YNCRCKRGMK KEKNCLRIYW SMYQSLQGND LLEDSPYEPV NSRLSDIFRV VPFISVEHIP KGNNCLDAAK ACNLDDICKK YRSAYITPCT TSVSNDVCNR RKCHKALRQF FDKVPAKHSY GMLFCSCRDI ACTERRRQTI VPVCSYEERE KPNCLNLQDS CKTNYICR |
Additional Info
| Function | Coreceptor for GDNF, a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. GDNF-binding leads to autophosphorylation and activation of the RET receptor. |
| Protein Name | Gdnf Family Receptor Alpha-1Gdnf Receptor Alpha-1Gdnfr-Alpha-1Gfr-Alpha-1Ret Ligand 1Tgf-Beta-Related Neurotrophic Factor Receptor 1 |
| Database Links | Reactome: R-HSA-419037Reactome: R-HSA-5673001Reactome: R-HSA-8853659Reactome: R-HSA-9830674 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorGolgi ApparatusTrans-Golgi NetworkEndosomeMultivesicular BodyLocalizes Mainly To The Plasma MembraneIn The Presence Of Sorl1Shifts To Vesicular StructuresIncluding Trans-Golgi NetworkEndosomes And Multivesicular Bodies |
| Alternative Protein Names | Gdnf Family Receptor Alpha-1 proteinGdnf Receptor Alpha-1 proteinGdnfr-Alpha-1 proteinGfr-Alpha-1 proteinRet Ligand 1 proteinTgf-Beta-Related Neurotrophic Factor Receptor 1 proteinGFRA1 proteinGDNFRA proteinRETL1 proteinTRNR1 protein |
Information sourced from Uniprot.org