| Function | Glycosyltransferase that catalyzes the transfer of an N-acetylglucosamine (GlcNAc) moiety in beta1-6 linkage from UDP-GlcNAc onto mucin-type core 1 O-glycan to form the branched mucin-type core 2 O-glycan. The catalysis is metal ion-independent and occurs with inversion of the anomeric configuration of sugar donor. Selectively involved in synthesis of mucin-type core 2 O-glycans that serve as scaffolds for the display of selectin ligand sialyl Lewis X epitope by myeloid cells, with an impact on homeostasis and recruitment to inflammatory sites. Can also act on glycolipid substrates. Transfers GlcNAc moiety to GalGb4Cer globosides in a reaction step to the synthesis of stage-specific embryonic antigen 1 (SSEA-1) determinant. Can use Galbeta1-3GalNAcalpha1- and Galbeta1-3GalNAcbeta1- oligosaccharide derivatives as acceptor substrates. |
| Protein Name | Beta-1 -3-Galactosyl-O-Glycosyl-Glycoprotein Beta-1 -6-N-AcetylglucosaminyltransferaseCore 2 Beta-1 -6-N-AcetylglucosaminyltransferaseC2glcnactCore 2-Branching EnzymeCore2-Glcnac-TransferaseC2gntCore 2 GntLeukocyte Type Core 2 Beta-1 -6-N-AcetylglucosaminyltransferaseC2gnt-L |
| Database Links | Reactome: R-HSA-913709 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane ProteinAlso Detected In The Trans-Golgi Network |
| Alternative Protein Names | Beta-1 -3-Galactosyl-O-Glycosyl-Glycoprotein Beta-1 -6-N-Acetylglucosaminyltransferase proteinCore 2 Beta-1 -6-N-Acetylglucosaminyltransferase proteinC2glcnact proteinCore 2-Branching Enzyme proteinCore2-Glcnac-Transferase proteinC2gnt proteinCore 2 Gnt proteinLeukocyte Type Core 2 Beta-1 -6-N-Acetylglucosaminyltransferase proteinC2gnt-L proteinGCNT1 proteinNACGT2 protein |
Information sourced from Uniprot.org
