SDS-PAGE gel of recombinant human G3BP2 protein 3 µg under reducing conditions stained with Coomassie blue

Human G3BP2 protein (Recombinant) (His-Tag) (STJP017467)

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STJP017467
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Short Description :Recombinant-Human G3BP2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:1 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 30% Glycerol, 0.2M NaCl, 2mM DTT, 0.1mM PMSF
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:G3BP2
Gene ID:9908
Uniprot ID:G3BP2_HUMAN
Accession Number:NP_987100.1
Immunogen:Human
Immunogen Region:1-449aa
Immunogen Sequence:MVMEKP SPLLVGREFV RQYYTLLNKA PEYLHRFYGR NSSYVHGGVD ASGKPQEAVY GQNDIHHKVL SLNFSECHTK IRHVDAHATL SDGVVVQVMG LLSNSGQPER KFMQTFVLAP EGSVPNKFYV HNDMFRYEDE VFGDSEPELD EESEDEVEEE QEERQPSPEP VQENANSGYY EAHPVTNGIE EPLEESSHEP EPEPES
Post Translational Modifications (Microbial infection) Cleaved by foot-and-mouth disease virus leader protease.this cleavage suppresses the formation of cytoplasmic stress granules.
Function Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling. Plays an essential role in stress granule formation. Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress. Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations.
Protein Name Ras Gtpase-Activating Protein-Binding Protein 2
G3bp-2
Gap Sh3 Domain-Binding Protein 2
Database Links Reactome: R-HSA-9705671
Cellular Localisation Cytoplasm
Stress Granule
Alternative Protein Names Ras Gtpase-Activating Protein-Binding Protein 2 protein
G3bp-2 protein
Gap Sh3 Domain-Binding Protein 2 protein
G3BP2 protein
KIAA0660 protein

Information sourced from Uniprot.org

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