Human G3BP2 protein (Recombinant) (His-Tag) (STJP017467)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human G3BP2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 30% Glycerol, 0.2M NaCl, 2mM DTT, 0.1mM PMSF |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | G3BP2 |
| Gene ID | 9908 |
| Uniprot ID | G3BP2_HUMAN |
| Accession Number | NP_987100.1 |
| Immunogen | Human |
| Immunogen Region | 1-449aa |
| Immunogen Sequence |
Additional Info
| Post Translational Modifications | (Microbial infection) Cleaved by foot-and-mouth disease virus leader protease.this cleavage suppresses the formation of cytoplasmic stress granules. |
| Function | Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling. Plays an essential role in stress granule formation. Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress. Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations. |
| Protein Name | Ras Gtpase-Activating Protein-Binding Protein 2G3bp-2Gap Sh3 Domain-Binding Protein 2 |
| Database Links | Reactome: R-HSA-9705671 |
| Cellular Localisation | CytoplasmStress Granule |
| Alternative Protein Names | Ras Gtpase-Activating Protein-Binding Protein 2 proteinG3bp-2 proteinGap Sh3 Domain-Binding Protein 2 proteinG3BP2 proteinKIAA0660 protein |
Information sourced from Uniprot.org