Human Fructosamine-3-kinase/FN3K protein (Recombinant) (His-Tag) (STJP017991)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Fructosamine-3-kinase/FN3K-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FN3K |
| Gene ID | 64122 |
| Uniprot ID | FN3K_HUMAN |
| Accession Number | NP_071441.1 |
| Immunogen | Human |
| Immunogen Region | 1-309aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Widely expressed. Expressed in erythrocytes. |
| Function | Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate. Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions. Involved in intracellular deglycation in erythrocytes. Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function. Also able to phosphorylate psicosamines and ribulosamines. |
| Protein Name | Fructosamine-3-KinaseProtein-Psicosamine 3-Kinase Fn3kProtein-Ribulosamine 3-Kinase Fn3k |
| Database Links | Reactome: R-HSA-163841 |
| Cellular Localisation | |
| Alternative Protein Names | Fructosamine-3-Kinase proteinProtein-Psicosamine 3-Kinase Fn3k proteinProtein-Ribulosamine 3-Kinase Fn3k proteinFN3K protein |
Information sourced from Uniprot.org