Human Fructosamine-3-kinase/FN3K protein (Recombinant) (His-Tag) (STJP017991)

SKU:
STJP017991
$185.61 - $1,019.13
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human Fructosamine-3-kinase/FN3K-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% Glycerol, 1mM DTT
Concentration: 0.25 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: FN3K
Gene ID: 64122
Uniprot ID: FN3K_HUMAN
Immunogen Region: 1-309aa
Accession Number: NP_071441.1
Immunogen: Human
Immunogen Sequence: MEQLLRA ELRTATLRAF GGPGAGCISE GRAYDTDAGP VFVKVNRRTQ ARQMFEGEVA SLEALRSTGL VRVPRPMKVI DLPGGGAAFV MEHLKMKSLS SQASKLGEQM ADLHLYNQKL REKLKEEENT VGRRGEGAEP QYVDKFGFHT VTCCGFIPQV NEWQDDWPTF FARHRLQAQL DLIEKDYADR EARELWSRLQ VKIPDL
Tissue Specificity Widely expressed. Expressed in erythrocytes.
Function Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate. Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions. Involved in intracellular deglycation in erythrocytes. Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function. Also able to phosphorylate psicosamines and ribulosamines.
Protein Name Fructosamine-3-Kinase
Protein-Psicosamine 3-Kinase Fn3k
Protein-Ribulosamine 3-Kinase Fn3k
Database Links Reactome: R-HSA-163841
Cellular Localisation
Alternative Protein Names Fructosamine-3-Kinase protein
Protein-Psicosamine 3-Kinase Fn3k protein
Protein-Ribulosamine 3-Kinase Fn3k protein
FN3K protein

Information sourced from Uniprot.org