Human FR-beta/FOLR2 protein (Recombinant) (C-His) (STJP020300)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human FR-beta/FOLR2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Thr17-Met228) of Human FR-beta/FOLR2 (Accession #) fused with His tag at the C-terminal.
General Information
| Short Description | Recombinant-Human FR-beta/FOLR2-C-His protein was developed in hek293 cells using the region Thr17-Met228. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | FOLR2 |
| Gene ID | 2350 |
| Uniprot ID | FOLR2_HUMAN |
| Immunogen | Recombinant Human FR-beta/FOLR2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Thr17-Met228) of Human FR-beta/FOLR2 (Accession #) fused with His tag at the C-terminal. |
| Immunogen Region | Thr17-Met228 |
Additional Info
| Tissue Specificity | Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues. |
| Post Translational Modifications | N-glycosylated. |
| Function | Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. |
| Protein Name | Folate Receptor BetaFr-BetaFolate Receptor 2Folate Receptor - Fetal/PlacentalPlacental Folate-Binding ProteinFbp |
| Database Links | Reactome: R-HSA-163125Reactome: R-HSA-196757 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorSecreted |
| Alternative Protein Names | Folate Receptor Beta proteinFr-Beta proteinFolate Receptor 2 proteinFolate Receptor - Fetal/Placental proteinPlacental Folate-Binding Protein proteinFbp proteinFOLR2 protein |
Information sourced from Uniprot.org