Human FR-beta/FOLR2 protein (Recombinant) (C-His) (STJP020300)

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STJP020300-100
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Host:HEK293 cells
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation:Unconjugated
Storage Instruction:Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method:< 1 EU/Mu g of the protein by LAL method.
Gene Symbol:FOLR2
Gene ID:2350
Uniprot ID:FOLR2_HUMAN
Immunogen:Recombinant Human FR-beta/FOLR2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Thr17-Met228) of Human FR-beta/FOLR2 (Accession #) fused with His tag at the C-terminal.
Immunogen Region:Thr17-Met228
Tissue Specificity Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues.
Post Translational Modifications N-glycosylated.
Function Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.
Protein Name Folate Receptor Beta
Fr-Beta
Folate Receptor 2
Folate Receptor - Fetal/Placental
Placental Folate-Binding Protein
Fbp
Database Links Reactome: R-HSA-163125
Reactome: R-HSA-196757
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Secreted
Alternative Protein Names Folate Receptor Beta protein
Fr-Beta protein
Folate Receptor 2 protein
Folate Receptor - Fetal/Placental protein
Placental Folate-Binding Protein protein
Fbp protein
FOLR2 protein

Information sourced from Uniprot.org

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