Human FR-beta/FOLR2 protein (Recombinant) (C-His) (STJP020300)

SKU:
STJP020300-100
£217.50
Free Shipping
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation: Unconjugated
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 1 EU/Mu g of the protein by LAL method.
Gene Symbol: FOLR2
Gene ID: 2350
Uniprot ID: FOLR2_HUMAN
Immunogen Region: Thr17-Met228
Immunogen: Recombinant Human FR-beta/FOLR2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Thr17-Met228) of Human FR-beta/FOLR2 (Accession #) fused with His tag at the C-terminal.
Tissue Specificity Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues.
Post Translational Modifications N-glycosylated.
Function Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.
Protein Name Folate Receptor Beta
Fr-Beta
Folate Receptor 2
Folate Receptor - Fetal/Placental
Placental Folate-Binding Protein
Fbp
Database Links Reactome: R-HSA-163125
Reactome: R-HSA-196757
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Secreted
Alternative Protein Names Folate Receptor Beta protein
Fr-Beta protein
Folate Receptor 2 protein
Folate Receptor - Fetal/Placental protein
Placental Folate-Binding Protein protein
Fbp protein
FOLR2 protein

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJP004093 Human FOLR2 protein (Recombinant) (N-His) (STJP004093) E.coli ELISA/Immunogen/SDS-PAGE/WB
STJP001983 Human FSH Beta protein (Recombinant) (C-His) (STJP001983) HEK293 cells
STJP001371 Human FR-alpha/FOLR1 protein (Recombinant) (C-His) (STJP001371) HEK293 cells
STJP003048 Human IFN-beta protein (Recombinant) (C-His) (STJP003048) HEK293 cells
STJP002079 Human Klotho beta/KLB protein (Recombinant) (C-His) (STJP002079) HEK293 cells

Related Products

!