Human FR-alpha/FOLR1 protein (Recombinant) (C-His) (STJP001371)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human FR-alpha/FOLR1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Arg25-Met233) of human FOLR-1/FBP (Accession #NP_000793.1) fused with a 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human FR-alpha/FOLR1-C-His protein was developed in hek293 cells using the region Arg25-Met233. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | <1 EU/Mu g |
Target Information
| Gene Symbol | FOLR1 |
| Gene ID | 2348 |
| Uniprot ID | FOLR1_HUMAN |
| Immunogen | Recombinant Human FR-alpha/FOLR1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Arg25-Met233) of human FOLR-1/FBP (Accession #NP_000793.1) fused with a 6×His tag at the C-terminus. |
| Immunogen Region | Arg25-Met233 |
| Immunogen Sequence | RIAWARTELLNVCMNAKHHK EKPGPEDKLHEQCRPWRKNA CCSTNTSQEAHKDVSYLYRF NWNHCGEMAPACKRHFIQDT CLYECSPNLGPWIQQVDQSW RKERVLNVPLCKEDCEQWWE DCRTSYTCKSNWHKGWNWTS GFNKCAVGAACQPFHFYFPT PTVLCNEIWTHSYKVSNYSR GSGRCIQMWFDPAQGNPNEE VARFYAAAM |
Additional Info
| Post Translational Modifications | The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. |
| Function | Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. |
| Protein Name | Folate Receptor AlphaFr-AlphaAdult Folate-Binding ProteinFbpFolate Receptor 1Folate Receptor - AdultKb Cells FbpOvarian Tumor-Associated Antigen Mov18 |
| Database Links | Reactome: R-HSA-204005Reactome: R-HSA-5694530Reactome: R-HSA-6807878 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorApical Cell MembraneBasolateral Cell MembraneGpi-Like-AnchorSecretedCytoplasmic VesicleClathrin-Coated VesicleEndosomeEndocytosed Into Cytoplasmic Vesicles And Then Recycled To The Cell Membrane |
| Alternative Protein Names | Folate Receptor Alpha proteinFr-Alpha proteinAdult Folate-Binding Protein proteinFbp proteinFolate Receptor 1 proteinFolate Receptor - Adult proteinKb Cells Fbp proteinOvarian Tumor-Associated Antigen Mov18 proteinFOLR1 proteinFOLR protein |
Information sourced from Uniprot.org