| Host: | Mammalian Cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Active-Human FGL1/HFREP1-N-hFc protein was developed from mammalian cells and has a target region of N-hFc. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Dilution Range: | Reconstitute in sterile water for a stock solution. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin: | <0.1 EU/Mu g of the protein by the LAL method. |
| Gene Symbol: | FGL1 |
| Gene ID: | 2267 |
| Uniprot ID: | FGL1_HUMAN |
| Immunogen Region: | Leu23-Ile312 |
| Immunogen: | Homo sapiens (Human) |
| Function | Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3. Responsible for LAG3 T-cell inhibitory function. Binds LAG3 independently from MHC class II (MHC-II). Secreted by, and promotes growth of, hepatocytes. |
| Protein Name | Fibrinogen-Like Protein 1Hp-041HepassocinHpsHepatocyte-Derived Fibrinogen-Related Protein 1Hfrep-1Liver Fibrinogen-Related Protein 1Lfire-1 |
| Cellular Localisation | SecretedSecreted In The Blood Plasma |
| Alternative Protein Names | Fibrinogen-Like Protein 1 proteinHp-041 proteinHepassocin proteinHps proteinHepatocyte-Derived Fibrinogen-Related Protein 1 proteinHfrep-1 proteinLiver Fibrinogen-Related Protein 1 proteinLfire-1 proteinFGL1 proteinHFREP1 protein |
Information sourced from Uniprot.org