Human FGL1/HFREP1 protein (Recombinant-Active) (N-hFc) (STJP012082)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Active-Human FGL1/HFREP1-N-hFc protein was developed from mammalian cells and has a target region of N-hFc. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity | Immobilised recombinant human FGL1/HFREP1 at 5 Mu g/mL (100 Mu L/well) can bind recombinant human LAG3 with a linear range of 0.5-21.6 ng/mL. |
Target Information
| Gene Symbol | FGL1 |
| Gene ID | 2267 |
| Uniprot ID | FGL1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Leu23-Ile312 |
Additional Info
| Function | Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3. Responsible for LAG3 T-cell inhibitory function. Binds LAG3 independently from MHC class II (MHC-II). Secreted by, and promotes growth of, hepatocytes. |
| Protein Name | Fibrinogen-Like Protein 1Hp-041HepassocinHpsHepatocyte-Derived Fibrinogen-Related Protein 1Hfrep-1Liver Fibrinogen-Related Protein 1Lfire-1 |
| Database Links | |
| Cellular Localisation | SecretedSecreted In The Blood Plasma |
| Alternative Protein Names | Fibrinogen-Like Protein 1 proteinHp-041 proteinHepassocin proteinHps proteinHepatocyte-Derived Fibrinogen-Related Protein 1 proteinHfrep-1 proteinLiver Fibrinogen-Related Protein 1 proteinLfire-1 proteinFGL1 proteinHFREP1 protein |
Information sourced from Uniprot.org