Human FGF-12 protein (Recombinant) (C-His) (STJP000840)
SPECIFICATIONS
HostE.coli
ConjugationUnconjugated
ImmunogenRecombinant Human FGF-12 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Met1-Thr181) of human FGF-12 (Accession #NP_004104.3) fused with a 6ΓHis tag at the C-terminus.
General Information
| Short Description | Recombinant-Human FGF-12-C-His protein was developed in e.coli using the region Met1-Thr181. For use in research applications. |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, 1mM DTT, 300mM NaCl, pH 7.4. |
| Storage Instruction | Store at-20Β°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Measured by its binding ability in a functional ELISA. Immobilized recombinant human FGFR4 at 5 Mu g/mL (100 Mu L/well) can bind recombinant human FGF12 with a linear range of 35-100 ng/mL. |
| Determination Method | < 1.0 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | FGF12 |
| Gene ID | 2257 |
| Uniprot ID | FGF12_HUMAN |
| Immunogen | Recombinant Human FGF-12 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Met1-Thr181) of human FGF-12 (Accession #NP_004104.3) fused with a 6ΓHis tag at the C-terminus. |
| Immunogen Region | Met1-Thr181 |
| Immunogen Sequence | MESKEPQLKGIVTRLFSQQG YFLQMHPDGTIDGTKDENSD YTLFNLIPVGLRVVAIQGVK ASLYVAMNGEGYLYSSDVFT PECKFKESVFENYYVIYSST LYRQQESGRAWFLGLNKEGQ IMKGNRVKKTKPSSHFVPKP IEVCMYREPSLHEIGEKQGR SRKSSGTPTMNGGKVVNQDS T |
Additional Info
| Tissue Specificity | Brain, eye and testis.highly expressed in embryonic retina, olfactory epithelium, olfactory bulb, and in a segmental pattern of the body wall.in adult olfactory bulb, less in cerebellum, deep cerebellar nuclei, cortex and multiple midbrain structures. |
| Function | Involved in nervous system development and function. Involved in the positive regulation of voltage-gated sodium channel activity. Promotes neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation. |
| Protein Name | Fibroblast Growth Factor 12Fgf-12Fibroblast Growth Factor Homologous Factor 1Fhf-1Myocyte-Activating Factor |
| Database Links | Reactome: R-HSA-5576892 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Fibroblast Growth Factor 12 proteinFgf-12 proteinFibroblast Growth Factor Homologous Factor 1 proteinFhf-1 proteinMyocyte-Activating Factor proteinFGF12 proteinFGF12B proteinFHF1 protein |
Information sourced from Uniprot.org