| Host: |
E. coli |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human FGF-12-C-His protein was developed from e. coli and has a target region of C-His. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, 1mM DTT, 300mM NaCl, pH 7.4. Contact us for customized product form or formulation. |
| Immunoreactivity: |
Measured by its binding ability in a functional ELISA. Immobilized recombinant human FGFR4 at 5 Mu g/mL (100 Mu L/well) can bind recombinant human FGF12 with a linear range of 35-100 ng/mL. |
| Gene Symbol: |
FGF12 |
| Gene ID: |
2257 |
| Uniprot ID: |
FGF12_HUMAN |
| Immunogen Region: |
Met1-Thr181 |
| Immunogen: |
Recombinant Human FGF-12 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Met1-Thr181) of human FGF-12 (Accession #NP_004104.3) fused with a 6×His tag at the C-terminus. |
| Tissue Specificity | Brain, eye and testis.highly expressed in embryonic retina, olfactory epithelium, olfactory bulb, and in a segmental pattern of the body wall.in adult olfactory bulb, less in cerebellum, deep cerebellar nuclei, cortex and multiple midbrain structures. |
| Function | Involved in nervous system development and function. Involved in the positive regulation of voltage-gated sodium channel activity. Promotes neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation. |
| Protein Name | Fibroblast Growth Factor 12Fgf-12Fibroblast Growth Factor Homologous Factor 1Fhf-1Myocyte-Activating Factor |
| Database Links | Reactome: R-HSA-5576892 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Fibroblast Growth Factor 12 proteinFgf-12 proteinFibroblast Growth Factor Homologous Factor 1 proteinFhf-1 proteinMyocyte-Activating Factor proteinFGF12 proteinFGF12B proteinFHF1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
