Human FCN1 protein (Recombinant) (N-His) (STJP003167)

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STJP003167
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human FCN1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: FCN1
Gene ID: 2219
Uniprot ID: FCN1_HUMAN
Immunogen Region: Ala30-Ala326
Immunogen: Homo sapiens (Human)
Function Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8. Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage.
Protein Name Ficolin-1
Collagen/Fibrinogen Domain-Containing Protein 1
Ficolin-A
Ficolin-Alpha
M-Ficolin
Database Links Reactome: R-HSA-166662
Reactome: R-HSA-166663
Reactome: R-HSA-2855086
Reactome: R-HSA-6798695
Cellular Localisation Secreted
Cell Membrane
Peripheral Membrane Protein
Extracellular Side
Found On The Monocyte And Granulocyte Surface
Alternative Protein Names Ficolin-1 protein
Collagen/Fibrinogen Domain-Containing Protein 1 protein
Ficolin-A protein
Ficolin-Alpha protein
M-Ficolin protein
FCN1 protein
FCNM protein

Information sourced from Uniprot.org

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