| Host: |
HEK293 |
| Note: |
STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human Fc gamma RIIIB/CD16b (NA2)-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications. |
| Conjugation: |
Biotin |
| Formulation: |
Lyophilised from 0.2 µm filtered PBS solution pH7.4. |
| Dilution Range: |
Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM |
| Storage Instruction: |
The lyophilized protein is stable for at least 1 year from date of receipt at-20°C. |
| Endotoxin: |
Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). |
| Gene Symbol: |
FCGR3B |
| Gene ID: |
2215 |
| Uniprot ID: |
FCG3B_HUMAN |
| Immunogen Region: |
Gly17-Ser200 |
| Immunogen: |
DNA sequence encoding Human Fc gamma RIIIB/CD16b (NA2) including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology. |
| Post Translational Modifications | Glycosylated. Glycosylation plays an inhibitory role in the interaction with IgG3. The soluble form is produced by a proteolytic cleavage. |
| Function | Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils. |
| Protein Name | Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-BFc-Gamma Riii-BetaCd16-IFc-Gamma RiiiFc-Gamma RiiibFcriiiFcriiibFcr-10Igg Fc Receptor Iii-1Cd Antigen Cd16b |
| Database Links | Reactome: R-HSA-163125Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorSecretedSecreted After Cleavage |
| Alternative Protein Names | Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-B proteinFc-Gamma Riii-Beta proteinCd16-I proteinFc-Gamma Riii proteinFc-Gamma Riiib proteinFcriii proteinFcriiib proteinFcr-10 proteinIgg Fc Receptor Iii-1 proteinCd Antigen Cd16b proteinFCGR3B proteinCD16B proteinFCG3 proteinFCGR3 proteinIGFR3 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
