• Biotinylated Human Fc gamma RIIIB (NA2) on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
  • The purity of Biotinylated Human Fc gamma RIIIB (NA2) is greater than 95% as determined by SEC-HPLC.
  • Biotinylated Human Fc gamma RIIIB (NA2) , His Tag captured on CM5 Chip via Anti-His Antibody can bind Rituximab, hFc Tag with an affinity constant of 4. 3 Mu M as determined in SPR assay (Biacore T200).

Human Fc gamma RIIIB/CD16b (NA2) protein (Recombinant) (C-His-Avi) {Biotin} (STJP001571)

SKU:
STJP001571

€773.13 - €2,386.88
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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human Fc gamma RIIIB/CD16b (NA2)-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications.
Conjugation: Biotin
Formulation: Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range: Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Storage Instruction: The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol: FCGR3B
Gene ID: 2215
Uniprot ID: FCG3B_HUMAN
Immunogen Region: Gly17-Ser200
Immunogen: DNA sequence encoding Human Fc gamma RIIIB/CD16b (NA2) including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Post Translational Modifications Glycosylated. Glycosylation plays an inhibitory role in the interaction with IgG3. The soluble form is produced by a proteolytic cleavage.
Function Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.
Protein Name Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-B
Fc-Gamma Riii-Beta
Cd16-I
Fc-Gamma Riii
Fc-Gamma Riiib
Fcriii
Fcriiib
Fcr-10
Igg Fc Receptor Iii-1
Cd Antigen Cd16b
Database Links Reactome: R-HSA-163125
Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Secreted
Secreted After Cleavage
Alternative Protein Names Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-B protein
Fc-Gamma Riii-Beta protein
Cd16-I protein
Fc-Gamma Riii protein
Fc-Gamma Riiib protein
Fcriii protein
Fcriiib protein
Fcr-10 protein
Igg Fc Receptor Iii-1 protein
Cd Antigen Cd16b protein
FCGR3B protein
CD16B protein
FCG3 protein
FCGR3 protein
IGFR3 protein

Information sourced from Uniprot.org

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