Human Fc-gamma RI/CD64 protein (Recombinant) (C-His) (STJP001241)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human Fc-gamma RI/CD64 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Pro288) of human Fc gamma RI/CD64 (Accession #NP_000557.1) fused with a 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human Fc-gamma RI/CD64-C-His protein was developed in hek293 cells using the region Met1-Pro288. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human FCGR1A, His Tag at 2 Mu g/mL (100 Mu L/well) can bind Rituximab with a linear range of 15.625-58.38 ng/mL. |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | FCGR1A |
| Gene ID | 2209 |
| Uniprot ID | FCGR1_HUMAN |
| Immunogen | Recombinant Human Fc-gamma RI/CD64 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Pro288) of human Fc gamma RI/CD64 (Accession #NP_000557.1) fused with a 6×His tag at the C-terminus. |
| Immunogen Region | Met1-Pro288 |
| Immunogen Sequence | MWFLTTLLLWVPVDGQVDTT KAVITLQPPWVSVFQEETVT LHCEVLHLPGSSSTQWFLNG TATQTSTPSYRITSASVNDS GEYRCQRGLSGRSDPIQLEI HRGWLLLQVSSRVFTEGEPL ALRCHAWKDKLVYNVLYYRN GKAFKFFHWNSNLTILKTNI SHNGTYHCSGMGKHRYTSAG ISVTVKELFPAPVLNASVTS PLLEGNLVTLSCETKLLLQR PGLQLYFSFYMGSKTLRGR |
Additional Info
| Post Translational Modifications | Phosphorylated on serine residues. |
| Function | High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. Mediates IgG effector functions on monocytes triggering antibody-dependent cellular cytotoxicity (ADCC) of virus-infected cells. |
| Protein Name | High Affinity Immunoglobulin Gamma Fc Receptor IIgg Fc Receptor IFc-Gamma RiFcriFc-Gamma RiaFcgammariaCd Antigen Cd64 |
| Database Links | Reactome: R-HSA-1236978Reactome: R-HSA-198933Reactome: R-HSA-2029481Reactome: R-HSA-2029482Reactome: R-HSA-2029485Reactome: R-HSA-877300Reactome: R-HSA-9664323 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinStabilized At The Cell Membrane Through Interaction With Fcer1g |
| Alternative Protein Names | High Affinity Immunoglobulin Gamma Fc Receptor I proteinIgg Fc Receptor I proteinFc-Gamma Ri proteinFcri proteinFc-Gamma Ria proteinFcgammaria proteinCd Antigen Cd64 proteinFCGR1A proteinFCG1 proteinFCGR1 proteinIGFR1 protein |
Information sourced from Uniprot.org