Host: |
HEK293 cells |
Reactivity: |
Human |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Recombinant-Human Fc-gamma RI/CD64-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications. |
Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation. |
Immunoreactivity: |
Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human FCGR1A, His Tag at 2 Mu g/mL (100 Mu L/well) can bind Rituximab with a linear range of 15.625-58.38 ng/mL. |
Gene Symbol: |
FCGR1A |
Gene ID: |
2209 |
Uniprot ID: |
FCGR1_HUMAN |
Immunogen: |
Recombinant Human Fc-gamma RI/CD64 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Pro288) of human Fc gamma RI/CD64 (Accession #NP_000557.1) fused with a 6Ă—His tag at the C-terminus. |
Post Translational Modifications | Phosphorylated on serine residues. |
Function | High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. Mediates IgG effector functions on monocytes triggering antibody-dependent cellular cytotoxicity (ADCC) of virus-infected cells. |
Protein Name | High Affinity Immunoglobulin Gamma Fc Receptor IIgg Fc Receptor IFc-Gamma RiFcriFc-Gamma RiaFcgammariaCd Antigen Cd64 |
Database Links | Reactome: R-HSA-1236978Reactome: R-HSA-198933Reactome: R-HSA-2029481Reactome: R-HSA-2029482Reactome: R-HSA-2029485Reactome: R-HSA-877300Reactome: R-HSA-9664323 |
Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinStabilized At The Cell Membrane Through Interaction With Fcer1g |
Alternative Protein Names | High Affinity Immunoglobulin Gamma Fc Receptor I proteinIgg Fc Receptor I proteinFc-Gamma Ri proteinFcri proteinFc-Gamma Ria proteinFcgammaria proteinCd Antigen Cd64 proteinFCGR1A proteinFCG1 proteinFCGR1 proteinIGFR1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance