Human FABP6 protein (Recombinant) (No-Tag) (STJP019622)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human FABP6-No-Tag protein was developed from e.coli and has a target region of No-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FABP6 |
| Gene ID | 2172 |
| Uniprot ID | FABP6_HUMAN |
| Accession Number | AAH22489 |
| Immunogen | Human |
| Immunogen Region | 1-128aa |
| Immunogen Sequence | MAFTGKFEME SEKNYDEFMK LLGISSDVIE KAHNFKIVTE VQQDGQDFTW SQHYYGGHTM TNKFTVGKES NIQTMGGKTF KATVQMEGGK LVVNFPNYHQ TSEIVGDKLV EVSTIGGVTY ERVSKRLA |
Additional Info
| Tissue Specificity | Isoform 1 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Isoform 2 is xpressed in the gallbladder, duodenum, jejunum, ileum, cecum, ascending, transverse and descending colon, sigmoid colon and rectum. Isoform 2 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level). |
| Function | Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes. In vitro binds to bile acids in the order: deoxycholic acid > cholic acid > chenodeoxycholic acid and respective BA conjugation modifies affinities in the order taurine-conjugated > glycine-conjugated > unconjugated bile acids. Stimulates gastric acid and pepsinogen secretion. Isoform 2: Essential for the survival of colon cancer cells to bile acid-induced apoptosis. |
| Protein Name | GastrotropinGtFatty Acid-Binding Protein 6Ileal Lipid-Binding ProteinIlbpIntestinal 15 Kda ProteinI-15pIntestinal Bile Acid-Binding ProteinI-Babp |
| Database Links | Reactome: R-HSA-159418Reactome: R-HSA-163560Reactome: R-HSA-9623433 |
| Cellular Localisation | Isoform 1: CytoplasmMembranePeripheral Membrane ProteinCytoplasmic SideIsoform 2: CytoplasmLocalized Close To Nucleus On The Apical Side Of Both Normal And Neoplastic Cells |
| Alternative Protein Names | Gastrotropin proteinGt proteinFatty Acid-Binding Protein 6 proteinIleal Lipid-Binding Protein proteinIlbp proteinIntestinal 15 Kda Protein proteinI-15p proteinIntestinal Bile Acid-Binding Protein proteinI-Babp proteinFABP6 proteinILBP proteinILLBP protein |
Information sourced from Uniprot.org