Human FABP5/E-FABP protein (Recombinant) (No-Tag) (STJP019623)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human FABP5/E-FABP-No-Tag protein was developed from e.coli and has a target region of No-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 20% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FABP5 |
| Gene ID | 2171 |
| Uniprot ID | FABP5_HUMAN |
| Accession Number | NP_001435 |
| Immunogen | Human |
| Immunogen Region | 1-135aa |
| Immunogen Sequence | MATVQQLEGR WRLVDSKGFD EYMKELGVGI ALRKMGAMAK PDCIITCDGK NLTIKTESTL KTTQFSCTLG EKFEETTADG RKTQTVCNFT DGALVQHQEW DGKESTITRK LKDGKLVVEC VMNNVTCTRI YEKVE |
Additional Info
| Tissue Specificity | Keratinocytes.highly expressed in psoriatic skin. Expressed in brain gray matter. |
| Function | Intracellular carrier for long-chain fatty acids and related active lipids, such as endocannabinoids, that regulate the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors. Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta.which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling. Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation. May be involved in keratinocyte differentiation. |
| Protein Name | Fatty Acid-Binding Protein 5Epidermal-Type Fatty Acid-Binding ProteinE-FabpFatty Acid-Binding Protein - EpidermalPsoriasis-Associated Fatty Acid-Binding Protein HomologPa-Fabp |
| Database Links | Reactome: R-HSA-163560Reactome: R-HSA-5362517Reactome: R-HSA-6798695Reactome: R-HSA-9725554 |
| Cellular Localisation | CytoplasmNucleusSynapsePostsynaptic DensitySecretedLocalizes Primarily To The CytoplasmUpon Certain Ligand BindingA Conformation Change Exposes A Nuclear Localization Motif And The Protein Is Transported Into NucleusSecreted By AstrocytesBut Not By Neurons |
| Alternative Protein Names | Fatty Acid-Binding Protein 5 proteinEpidermal-Type Fatty Acid-Binding Protein proteinE-Fabp proteinFatty Acid-Binding Protein - Epidermal proteinPsoriasis-Associated Fatty Acid-Binding Protein Homolog proteinPa-Fabp proteinFABP5 protein |
Information sourced from Uniprot.org