Human DOC2B protein (Recombinant) (N-His) (STJP005386)

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STJP005386
€410.63 - €1,796.88
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human DOC2B-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: DOC2B
Gene ID: 8447
Uniprot ID: DOC2B_HUMAN
Immunogen Region: Gly173-Arg397
Immunogen: Homo sapiens (Human)
Function Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes.
Protein Name Double C2-Like Domain-Containing Protein Beta
Doc2-Beta
Cellular Localisation Cytoplasm
Cytoplasmic Granule
Cell Membrane
Peripheral Membrane Protein
Translocates To The Plasma Membrane In A Calcium-Dependent Manner
Alternative Protein Names Double C2-Like Domain-Containing Protein Beta protein
Doc2-Beta protein
DOC2B protein
DOC2BL protein

Information sourced from Uniprot.org

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