Human DNAJB9 protein (Recombinant) (N-His) (STJP007771)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human DNAJB9-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | DNAJB9 |
| Gene ID | 4189 |
| Uniprot ID | DNJB9_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser24-Gln223 |
Additional Info
| Function | Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins. In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1. Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production. |
| Protein Name | Dnaj Homolog Subfamily B Member 9Endoplasmic Reticulum Dna J Domain-Containing Protein 4Er-Resident Protein Erdj4Erdj4Microvascular Endothelial Differentiation Gene 1 ProteinMdg-1 |
| Database Links | Reactome: R-HSA-381038 |
| Cellular Localisation | Endoplasmic Reticulum Lumen |
| Alternative Protein Names | Dnaj Homolog Subfamily B Member 9 proteinEndoplasmic Reticulum Dna J Domain-Containing Protein 4 proteinEr-Resident Protein Erdj4 proteinErdj4 proteinMicrovascular Endothelial Differentiation Gene 1 Protein proteinMdg-1 proteinDNAJB9 proteinMDG1 proteinUNQ743 proteinPRO1471 protein |
Information sourced from Uniprot.org