Human DNAJB9 protein (Recombinant) (N-His) (STJP007771)

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STJP007771
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Short Description :Recombinant-Human DNAJB9-N-His protein was developed from e.coli for the region N-His. For use in research applications.
Applications:ELISA/Immunogen/SDS-PAGE/WB
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Dilution Range:Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Formulation:Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol:DNAJB9
Gene ID:4189
Uniprot ID:DNJB9_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Ser24-Gln223
Function Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins. In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1. Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production.
Protein Name Dnaj Homolog Subfamily B Member 9
Endoplasmic Reticulum Dna J Domain-Containing Protein 4
Er-Resident Protein Erdj4
Erdj4
Microvascular Endothelial Differentiation Gene 1 Protein
Mdg-1
Database Links Reactome: R-HSA-381038
Cellular Localisation Endoplasmic Reticulum Lumen
Alternative Protein Names Dnaj Homolog Subfamily B Member 9 protein
Endoplasmic Reticulum Dna J Domain-Containing Protein 4 protein
Er-Resident Protein Erdj4 protein
Erdj4 protein
Microvascular Endothelial Differentiation Gene 1 Protein protein
Mdg-1 protein
DNAJB9 protein
MDG1 protein
UNQ743 protein
PRO1471 protein

Information sourced from Uniprot.org