Human DNA polymerase lambda/POLL protein (Recombinant) (His-Tag) (STJP017380)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Dpolymerase lambda/POLL-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 30% Glycerol, 0.1M NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | POLL |
| Gene ID | 27343 |
| Uniprot ID | DPOLL_HUMAN |
| Accession Number | AAH03548 |
| Immunogen | Human |
| Immunogen Region | 1-300aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Expressed in a number of tissues. Abundant in testis. |
| Function | DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Also has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. |
| Protein Name | Dna Polymerase LambdaPol LambdaDna Polymerase Beta-2Pol Beta2Dna Polymerase Kappa |
| Database Links | Reactome: R-HSA-5693571 |
| Cellular Localisation | NucleusChromosomeAccumulates At Sites Of Dna Damage |
| Alternative Protein Names | Dna Polymerase Lambda proteinPol Lambda proteinDna Polymerase Beta-2 proteinPol Beta2 proteinDna Polymerase Kappa proteinPOLL protein |
Information sourced from Uniprot.org