| Post Translational Modifications | Phosphorylated. Phosphorylation at Ser-403 by PKA causes the C-terminal headpiece domain to associate with the N-terminal core domain, and leads to the inhibition of its actin bundling activity. The N-terminus is blocked. |
| Function | Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts.acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. |
| Protein Name | DematinDematin Actin-Binding ProteinErythrocyte Membrane Protein Band 4.9 |
| Database Links | Reactome: R-HSA-5223345 |
| Cellular Localisation | CytoplasmCytosolPerinuclear RegionCytoskeletonCell MembraneMembraneEndomembrane SystemCell ProjectionLocalized At The Spectrin-Actin Junction Of Erythrocyte Plasma MembraneLocalized To Intracellular Membranes And The Cytoskeletal NetworkLocalized At Intracellular Membrane-Bounded Organelle Compartment In Platelets That Likely Represent The Dense Tubular Network MembraneDetected At The Cell Membrane And At The Parasitophorous Vacuole In Malaria-Infected Erythrocytes At Late Stages Of Plasmodium Berghei Or Falciparum Development |
| Alternative Protein Names | Dematin proteinDematin Actin-Binding Protein proteinErythrocyte Membrane Protein Band 4.9 proteinDMTN proteinDMT proteinEPB49 protein |
Information sourced from Uniprot.org
