Human DMTN protein (Recombinant) (N-His) (STJP005234)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human DMTN-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | DMTN |
| Gene ID | 2039 |
| Uniprot ID | DEMA_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Ser269 |
Additional Info
| Post Translational Modifications | Phosphorylated. Phosphorylation at Ser-403 by PKA causes the C-terminal headpiece domain to associate with the N-terminal core domain, and leads to the inhibition of its actin bundling activity. The N-terminus is blocked. |
| Function | Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts.acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. |
| Protein Name | DematinDematin Actin-Binding ProteinErythrocyte Membrane Protein Band 4.9 |
| Database Links | Reactome: R-HSA-5223345 |
| Cellular Localisation | CytoplasmCytosolPerinuclear RegionCytoskeletonCell MembraneMembraneEndomembrane SystemCell ProjectionLocalized At The Spectrin-Actin Junction Of Erythrocyte Plasma MembraneLocalized To Intracellular Membranes And The Cytoskeletal NetworkLocalized At Intracellular Membrane-Bounded Organelle Compartment In Platelets That Likely Represent The Dense Tubular Network MembraneDetected At The Cell Membrane And At The Parasitophorous Vacuole In Malaria-Infected Erythrocytes At Late Stages Of Plasmodium Berghei Or Falciparum Development |
| Alternative Protein Names | Dematin proteinDematin Actin-Binding Protein proteinErythrocyte Membrane Protein Band 4.9 proteinDMTN proteinDMT proteinEPB49 protein |
Information sourced from Uniprot.org