Human DHCR24 protein (Recombinant) (N-His) (STJP005447)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human DHCR24-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | DHCR24 |
| Gene ID | 1718 |
| Uniprot ID | DHC24_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Arg53-His516 |
Additional Info
| Function | Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis. |
| Protein Name | Delta(24-Sterol Reductase24-Dehydrocholesterol Reductase3-Beta-Hydroxysterol Delta-24-ReductaseDiminuto/Dwarf1 HomologSeladin-1 |
| Database Links | Reactome: R-HSA-191273Reactome: R-HSA-6807047Reactome: R-HSA-6807062 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinGolgi Apparatus Membrane |
| Alternative Protein Names | Delta(24-Sterol Reductase protein24-Dehydrocholesterol Reductase protein3-Beta-Hydroxysterol Delta-24-Reductase proteinDiminuto/Dwarf1 Homolog proteinSeladin-1 proteinDHCR24 proteinKIAA0018 protein |
Information sourced from Uniprot.org