SDS-PAGE gel of recombinant human DCXR protein under reducing conditions stained with Coomassie blue

Human DCXR protein (Recombinant) (His-Tag) (STJP019311)

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STJP019311
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Short Description :Recombinant-Human DCXR-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE/Enzyme Activity
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:0.5 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 20% Glycerol, 50mM NaCl
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Immunoreactivity:Specific activity is > 1, 800pmol/min/ug and is defined as the amount of enzyme that oxidize 1pmole of xylitol to L-xylulose per minute at pH 10.0 at 37C.
Gene Symbol:DCXR
Gene ID:51181
Uniprot ID:DCXR_HUMAN
Accession Number:NP_057370
Immunogen:Human
Immunogen Region:1-244aa
Immunogen Sequence:MGSSHHHHHH SSGLVPRGSH MELFLAGRRV LVTGAGKGIG RGTVQALHAT GARVVAVSRT QADLDSLVRE CPGIEPVCVD LGDWEATERA LGSVGPVDLL VNNAAVALLQ PFLEVTKEAF DRSFEVNLRA VIQVSQIVAR GLIARGVPGA IVNVSSQCSQ RAVTNHSVYC STKGALDMLT KVMALELGPH KIRVNAVNPT VVMTSMGQAT WSDPHKAKTM LNRIPLGK
Tissue Specificity Highly expressed in kidney, liver and epididymis. In the epididymis, it is mainly expressed in the proximal and distal sections of the corpus region. Weakly or not expressed in brain, lung, heart, spleen and testis.
Function Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.
Protein Name L-Xylulose Reductase
Xr
Carbonyl Reductase Ii
Dicarbonyl/L-Xylulose Reductase
Kidney Dicarbonyl Reductase
Kidcr
Short Chain Dehydrogenase/Reductase Family 20c Member 1
Sperm Surface Protein P34h
Database Links Reactome: R-HSA-5661270
Reactome: R-HSA-5662853
Cellular Localisation Membrane
Peripheral Membrane Protein
Probably Recruited To Membranes Via An Interaction With Phosphatidylinositol
Alternative Protein Names L-Xylulose Reductase protein
Xr protein
Carbonyl Reductase Ii protein
Dicarbonyl/L-Xylulose Reductase protein
Kidney Dicarbonyl Reductase protein
Kidcr protein
Short Chain Dehydrogenase/Reductase Family 20c Member 1 protein
Sperm Surface Protein P34h protein
DCXR protein
SDR20C1 protein

Information sourced from Uniprot.org

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