Human DCXR protein (Recombinant) (His-Tag) (STJP019311)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human DCXR-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Enzyme Activity |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 20% Glycerol, 50mM NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Specific activity is > 1, 800pmol/min/ug and is defined as the amount of enzyme that oxidize 1pmole of xylitol to L-xylulose per minute at pH 10.0 at 37C. |
Target Information
| Gene Symbol | DCXR |
| Gene ID | 51181 |
| Uniprot ID | DCXR_HUMAN |
| Accession Number | NP_057370 |
| Immunogen | Human |
| Immunogen Region | 1-244aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MELFLAGRRV LVTGAGKGIG RGTVQALHAT GARVVAVSRT QADLDSLVRE CPGIEPVCVD LGDWEATERA LGSVGPVDLL VNNAAVALLQ PFLEVTKEAF DRSFEVNLRA VIQVSQIVAR GLIARGVPGA IVNVSSQCSQ RAVTNHSVYC STKGALDMLT KVMALELGPH KIRVNAVNPT VVMTSMGQAT WSDPHKAKTM LNRIPLGK |
Additional Info
| Tissue Specificity | Highly expressed in kidney, liver and epididymis. In the epididymis, it is mainly expressed in the proximal and distal sections of the corpus region. Weakly or not expressed in brain, lung, heart, spleen and testis. |
| Function | Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules. |
| Protein Name | L-Xylulose ReductaseXrCarbonyl Reductase IiDicarbonyl/L-Xylulose ReductaseKidney Dicarbonyl ReductaseKidcrShort Chain Dehydrogenase/Reductase Family 20c Member 1Sperm Surface Protein P34h |
| Database Links | Reactome: R-HSA-5661270Reactome: R-HSA-5662853 |
| Cellular Localisation | MembranePeripheral Membrane ProteinProbably Recruited To Membranes Via An Interaction With Phosphatidylinositol |
| Alternative Protein Names | L-Xylulose Reductase proteinXr proteinCarbonyl Reductase Ii proteinDicarbonyl/L-Xylulose Reductase proteinKidney Dicarbonyl Reductase proteinKidcr proteinShort Chain Dehydrogenase/Reductase Family 20c Member 1 proteinSperm Surface Protein P34h proteinDCXR proteinSDR20C1 protein |
Information sourced from Uniprot.org