| Function | A cytochrome P450 monooxygenase involved in vitamin D metabolism and in calcium and phosphorus homeostasis. Catalyzes the rate-limiting step in the activation of vitamin D in the kidney, namely the hydroxylation of 25-hydroxyvitamin D3/calcidiol at the C1alpha-position to form the hormonally active form of vitamin D3, 1alpha,25-dihydroxyvitamin D3/calcitriol that acts via the vitamin D receptor (VDR). Has 1alpha-hydroxylase activity on vitamin D intermediates of the CYP24A1-mediated inactivation pathway. Converts 24R,25-dihydroxyvitamin D3/secalciferol to 1-alpha,24,25-trihydroxyvitamin D3, an active ligand of VDR. Also active on 25-hydroxyvitamin D2. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via FDXR/adrenodoxin reductase and FDX1/adrenodoxin. |
| Protein Name | 25-Hydroxyvitamin D-1 Alpha Hydroxylase - Mitochondrial25-Ohd-1 Alpha-Hydroxylase25-Hydroxyvitamin D(3 1-Alpha-HydroxylaseVd3 1a HydroxylaseCalcidiol 1-MonooxygenaseCytochrome P450 Subfamily Xxviib Polypeptide 1Cytochrome P450c1 AlphaCytochrome P450vd1-AlphaCytochrome P450 27b1 |
| Database Links | Reactome: R-HSA-196791Reactome: R-HSA-211916Reactome: R-HSA-5579014 |
| Cellular Localisation | Mitochondrion Membrane |
| Alternative Protein Names | 25-Hydroxyvitamin D-1 Alpha Hydroxylase - Mitochondrial protein25-Ohd-1 Alpha-Hydroxylase protein25-Hydroxyvitamin D(3 1-Alpha-Hydroxylase proteinVd3 1a Hydroxylase proteinCalcidiol 1-Monooxygenase proteinCytochrome P450 Subfamily Xxviib Polypeptide 1 proteinCytochrome P450c1 Alpha proteinCytochrome P450vd1-Alpha proteinCytochrome P450 27b1 proteinCYP27B1 proteinCYP1ALPHA proteinCYP27B protein |
Information sourced from Uniprot.org
