Human Cyclophilin H/PPIH protein (Recombinant) (No-Tag) (STJP019733)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Cyclophilin H/PPIH-No-Tag protein was developed from e.coli and has a target region of No-Tag. For use in research applications. |
| Applications | SDS-PAGE/Enzyme Activity |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Endotoxin | < 1 EU per 1ug of protein (determined by LAL method) |
| Immunoreactivity | Specific activity is > 220nmol/min/mg, and is defined as the amount of enzyme that cleaves 1umole of suc-AAPF-pNA per minute at 37C in Tris-Hcl pH8.0 using chymotrypsin. |
Target Information
| Gene Symbol | PPIH |
| Gene ID | 10465 |
| Uniprot ID | PPIH_HUMAN |
| Accession Number | NP_006338 |
| Immunogen | Human |
| Immunogen Region | 1-177aa |
| Immunogen Sequence | MAVANSSPVN PVVFFDVSIG GQEVGRMKIE LFADVVPKTA ENFRQFCTGE FRKDGVPIGY KGSTFHRVIK DFMIQGGDFV NGDGTGVASI YRGPFADENF KLRHSAPGLL SMANSGPSTN GCQFFITCSK CDWLDGKHVV FGKIIDGLLV MRKIENVPTG PNNKPKLPVV ISQCGEM |
Additional Info
| Function | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone. |
| Protein Name | Peptidyl-Prolyl Cis-Trans Isomerase HPpiase HRotamase HSmall Nuclear Ribonucleoprotein Particle-Specific Cyclophilin HCyphU-Snrnp-Associated Cyclophilin Snucyp-20Usa-Cyp |
| Database Links | Reactome: R-HSA-72163Reactome: R-HSA-9692916 |
| Cellular Localisation | Nucleus SpeckleCytoplasmColocalizes With Spliceosomal SnrnpsA Small Proportion May Also Be Cytoplasmic |
| Alternative Protein Names | Peptidyl-Prolyl Cis-Trans Isomerase H proteinPpiase H proteinRotamase H proteinSmall Nuclear Ribonucleoprotein Particle-Specific Cyclophilin H proteinCyph proteinU-Snrnp-Associated Cyclophilin Snucyp-20 proteinUsa-Cyp proteinPPIH proteinCYP20 proteinCYPH protein |
Information sourced from Uniprot.org