Human COMMD6 protein (Recombinant) (His-Tag) (STJP018865)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human COMMD6-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH7.0) containing 20% Glycerol 0.15M NaCl, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | COMMD6 |
| Gene ID | 170622 |
| Uniprot ID | COMD6_HUMAN |
| Accession Number | NP_987091.1 |
| Immunogen | Human |
| Immunogen Region | 1-85aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Ubiquitous. Expressed in brain, heart, skeletal muscle, lung, pancreas, liver, kidney, small intestine and placenta. |
| Function | Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos.the commander complex is composed of the CCC subcomplex and the retriever subcomplex. May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Down-regulates activation of NF-kappa-B. Inhibits TNF-induced NFKB1 activation. |
| Protein Name | Comm Domain-Containing Protein 6 |
| Database Links | Reactome: R-HSA-8951664 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Protein Names | Comm Domain-Containing Protein 6 proteinCOMMD6 proteinMSTP076 protein |
Information sourced from Uniprot.org