Human CNTN1 protein (Recombinant) (N-His) (STJP005259)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CNTN1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CNTN1 |
| Gene ID | 1272 |
| Uniprot ID | CNTN1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Tyr736-Leu1003 |
Additional Info
| Function | Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth. |
| Protein Name | Contactin-1Glycoprotein Gp135Neural Cell Surface Protein F3 |
| Database Links | Reactome: R-HSA-2122948Reactome: R-HSA-2979096Reactome: R-HSA-373760Reactome: R-HSA-447043 |
| Cellular Localisation | Isoform 1: Cell MembraneLipid-AnchorGpi-AnchorExtracellular SideIsoform 2: Cell Membrane |
| Alternative Protein Names | Contactin-1 proteinGlycoprotein Gp135 proteinNeural Cell Surface Protein F3 proteinCNTN1 protein |
Information sourced from Uniprot.org