Human CNTN1 protein (Recombinant) (N-His) (STJP005259)

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STJP005259
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CNTN1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: CNTN1
Gene ID: 1272
Uniprot ID: CNTN1_HUMAN
Immunogen Region: Tyr736-Leu1003
Immunogen: Homo sapiens (Human)
Function Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth.
Protein Name Contactin-1
Glycoprotein Gp135
Neural Cell Surface Protein F3
Database Links Reactome: R-HSA-2122948
Reactome: R-HSA-2979096
Reactome: R-HSA-373760
Reactome: R-HSA-447043
Cellular Localisation Isoform 1: Cell Membrane
Lipid-Anchor
Gpi-Anchor
Extracellular Side
Isoform 2: Cell Membrane
Alternative Protein Names Contactin-1 protein
Glycoprotein Gp135 protein
Neural Cell Surface Protein F3 protein
CNTN1 protein

Information sourced from Uniprot.org

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