Human CLEC7A/Dectin-1/CD369 protein (Recombinant) (N-raFc) (STJP001517)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human CLEC7A/Dectin-1/CD369 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Thr66-Met247) of human CLEC7A/Dectin-1/CD369 (Accession #NP_922938.1) fused with a raFc tag at the N-terminu
General Information
| Short Description | Recombinant-Human CLEC7A/Dectin-1/CD369-N-raFc protein was developed in hek293 cells using the region Thr66-Met247. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | <0.1 EU/Mu g |
Target Information
| Gene Symbol | CLEC7A |
| Gene ID | 64581 |
| Uniprot ID | CLC7A_HUMAN |
| Immunogen | Recombinant Human CLEC7A/Dectin-1/CD369 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Thr66-Met247) of human CLEC7A/Dectin-1/CD369 (Accession #NP_922938.1) fused with a raFc tag at the N-terminu |
| Immunogen Region | Thr66-Met247 |
| Immunogen Sequence | TMAIWRSNSGSNTLENGYFL SRNKENHSQPTQSSLEDSVT PTKAVKTTGVLSSPCPPNWI IYEKSCYLFSMSLNSWDGSK RQCWQLGSNLLKIDSSNELG FIVKQVSSQPDNSFWIGLSR PQTEVPWLWEDGSTFSSNLF QIRTTATQENPSPNCVWIHV SVIYDQLCSVPSYSICEKKF SM |
Additional Info
| Post Translational Modifications | Phosphorylated on tyrosine residues in response to beta-glucan binding. |
| Function | Lectin that functions as a pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Induces phosphorylation of SCIMP after binding beta-glucans. |
| Protein Name | C-Type Lectin Domain Family 7 Member ABeta-Glucan ReceptorC-Type Lectin Superfamily Member 12Dendritic Cell-Associated C-Type Lectin 1Dc-Associated C-Type Lectin 1Dectin-1Cd Antigen Cd369 |
| Database Links | Reactome: R-HSA-5607764 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinIsoform 5: CytoplasmIsoform 6: CytoplasmIsoform 7: Cytoplasm |
| Alternative Protein Names | C-Type Lectin Domain Family 7 Member A proteinBeta-Glucan Receptor proteinC-Type Lectin Superfamily Member 12 proteinDendritic Cell-Associated C-Type Lectin 1 proteinDc-Associated C-Type Lectin 1 proteinDectin-1 proteinCd Antigen Cd369 proteinCLEC7A proteinBGR proteinCLECSF12 proteinDECTIN1 proteinUNQ539 proteinPRO1082 protein |
Information sourced from Uniprot.org