| Host: |
HEK293 cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human CLEC7A/Dectin-1/CD369-N-raFc protein was developed from hek293 cells and has a target region of N-raFc. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Gene Symbol: |
CLEC7A |
| Gene ID: |
64581 |
| Uniprot ID: |
CLC7A_HUMAN |
| Immunogen: |
Recombinant Human CLEC7A/Dectin-1/CD369 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Thr66-Met247) of human CLEC7A/Dectin-1/CD369 (Accession #NP_922938.1) fused with a raFc tag at the N-terminu |
| Post Translational Modifications | Phosphorylated on tyrosine residues in response to beta-glucan binding. |
| Function | Lectin that functions as pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Induces phosphorylation of SCIMP after binding beta-glucans. |
| Protein Name | C-Type Lectin Domain Family 7 Member ABeta-Glucan ReceptorC-Type Lectin Superfamily Member 12Dendritic Cell-Associated C-Type Lectin 1Dc-Associated C-Type Lectin 1Dectin-1Cd Antigen Cd369 |
| Database Links | Reactome: R-HSA-5607764 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinIsoform 5: CytoplasmIsoform 6: CytoplasmIsoform 7: Cytoplasm |
| Alternative Protein Names | C-Type Lectin Domain Family 7 Member A proteinBeta-Glucan Receptor proteinC-Type Lectin Superfamily Member 12 proteinDendritic Cell-Associated C-Type Lectin 1 proteinDc-Associated C-Type Lectin 1 proteinDectin-1 proteinCd Antigen Cd369 proteinCLEC7A proteinBGR proteinCLECSF12 proteinDECTIN1 proteinUNQ539 proteinPRO1082 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
