SDS-PAGE of recombinant human CLEC-2 CLEC1B protein under reducing conditions

Human CLEC-2/CLEC1B protein (Recombinant) (His-Tag) (STJP019091)

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STJP019091
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Short Description :Recombinant-Human CLEC-2/CLEC1B-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE/Denatured
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:1 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:CLEC1B
Gene ID:51266
Uniprot ID:CLC1B_HUMAN
Accession Number:NP_057593
Immunogen:Human
Immunogen Region:55-229aa
Immunogen Sequence:SVMQRNY LQGENENRTG TLQQLAKRFC QYVVKQSELK GTFKGHKCSP CDTNWRYYGD SCYGFFRHNL TWEESKQYCT DMNATLLKID NRNIVEYIKA RTHLIRWVGL SRQKSNEVWK WEDGSVISEN MFEFLEDGKG NMNCAYFHNG KMHPTFCENK HYLMCERKAG MTKVDQLP
Tissue Specificity Expressed preferentially in the liver. Also expressed in immune cells of myeloid origin and on the surface of platelets.
Post Translational Modifications Glycosylated. Phosphorylated on tyrosine residue in response to rhodocytin binding.
Function C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN. After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2. (Microbial infection) Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (SYK) and initiation of downstream tyrosine phosphorylation events and activation of PLCG2. (Microbial infection) Acts as an attachment factor for Human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets.
Protein Name C-Type Lectin Domain Family 1 Member B
C-Type Lectin-Like Receptor 2
Clec-2
Database Links Reactome: R-HSA-114604
Reactome: R-HSA-9707616
Cellular Localisation Membrane
Single-Pass Type Ii Membrane Protein
Alternative Protein Names C-Type Lectin Domain Family 1 Member B protein
C-Type Lectin-Like Receptor 2 protein
Clec-2 protein
CLEC1B protein
CLEC2 protein
UNQ721 protein
PRO1384 protein

Information sourced from Uniprot.org

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