Human CLEC-2/CLEC1B protein (Recombinant) (His-Tag) (STJP019091)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human CLEC-2/CLEC1B-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CLEC1B |
| Gene ID | 51266 |
| Uniprot ID | CLC1B_HUMAN |
| Accession Number | NP_057593 |
| Immunogen | Human |
| Immunogen Region | 55-229aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Expressed preferentially in the liver. Also expressed in immune cells of myeloid origin and on the surface of platelets. |
| Post Translational Modifications | Glycosylated. Phosphorylated on tyrosine residue in response to rhodocytin binding. |
| Function | C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN. After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2. (Microbial infection) Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (SYK) and initiation of downstream tyrosine phosphorylation events and activation of PLCG2. (Microbial infection) Acts as an attachment factor for Human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets. |
| Protein Name | C-Type Lectin Domain Family 1 Member BC-Type Lectin-Like Receptor 2Clec-2 |
| Database Links | Reactome: R-HSA-114604Reactome: R-HSA-9707616 |
| Cellular Localisation | MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Protein Names | C-Type Lectin Domain Family 1 Member B proteinC-Type Lectin-Like Receptor 2 proteinClec-2 proteinCLEC1B proteinCLEC2 proteinUNQ721 proteinPRO1384 protein |
Information sourced from Uniprot.org