Human CHP2 protein (Recombinant) (N-His) (STJP010689)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CHP2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CHP2 |
| Gene ID | 63928 |
| Uniprot ID | CHP2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asp13-Lys196 |
Additional Info
| Function | Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus. |
| Protein Name | Calcineurin B Homologous Protein 2Hepatocellular Carcinoma-Associated Antigen 520 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmCell MembranePredominantly Localized In A Juxtanuclear RegionColocalizes With Slc9a3 In The Juxtanuclear Region And At The Plasma MembraneExported From The Nucleus To The Cytoplasm Through A Nuclear Export Signal (Nes) PathwayMay Shuttle Between Nucleus And Cytoplasm |
| Alternative Protein Names | Calcineurin B Homologous Protein 2 proteinHepatocellular Carcinoma-Associated Antigen 520 proteinCHP2 proteinHCA520 protein |
Information sourced from Uniprot.org