Human CHP2 protein (Recombinant) (N-His) (STJP010689)

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STJP010689
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CHP2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: CHP2
Gene ID: 63928
Uniprot ID: CHP2_HUMAN
Immunogen Region: Asp13-Lys196
Immunogen: Homo sapiens (Human)
Function Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus.
Protein Name Calcineurin B Homologous Protein 2
Hepatocellular Carcinoma-Associated Antigen 520
Cellular Localisation Nucleus
Cytoplasm
Cell Membrane
Predominantly Localized In A Juxtanuclear Region
Colocalizes With Slc9a3 In The Juxtanuclear Region And At The Plasma Membrane
Exported From The Nucleus To The Cytoplasm Through A Nuclear Export Signal (Nes) Pathway
May Shuttle Between Nucleus And Cytoplasm
Alternative Protein Names Calcineurin B Homologous Protein 2 protein
Hepatocellular Carcinoma-Associated Antigen 520 protein
CHP2 protein
HCA520 protein

Information sourced from Uniprot.org

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