| Post Translational Modifications | (Microbial infection) Stearoylated By S.flexneri N-epsilon-fatty acyltransferase IcsB, promoting S.flexneri evasion of autophagy. ISGylated. Isgylation inhibits its interaction with VTA1. |
| Function | Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release. |
| Protein Name | Charged Multivesicular Body Protein 5Chromatin-Modifying Protein 5Snf7 Domain-Containing Protein 2Vacuolar Protein Sorting-Associated Protein 60Vps60Hvps60 |
| Database Links | Reactome: R-HSA-162588Reactome: R-HSA-917729 |
| Cellular Localisation | CytoplasmCytosolEndosome MembranePeripheral Membrane ProteinMidbodyLocalizes To The Midbody Of Dividing CellsLocalized In Two Distinct Rings On Either Side Of The Flemming Body |
| Alternative Protein Names | Charged Multivesicular Body Protein 5 proteinChromatin-Modifying Protein 5 proteinSnf7 Domain-Containing Protein 2 proteinVacuolar Protein Sorting-Associated Protein 60 proteinVps60 proteinHvps60 proteinCHMP5 proteinC9orf83 proteinSNF7DC2 proteinCGI-34 proteinHSPC177 proteinPNAS-114 proteinPNAS-2 protein |
Information sourced from Uniprot.org
