Human CERT1 protein (Recombinant) (His-Tag) (STJP016719)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human CERT1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol 0.1M NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CERT1 |
| Gene ID | 10087 |
| Uniprot ID | CERT_HUMAN |
| Accession Number | NP_112729 |
| Immunogen | Human |
| Immunogen Region | 347-598aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Phosphorylation on Ser-132 decreases the affinity toward phosphatidylinositol 4-phosphate at Golgi membranes and reduces ceramide transfer activity. Inactivated by hyperphosphorylation of serine residues by CSNK1G2/CK1 that triggers dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. |
| Function | Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. |
| Protein Name | Ceramide Transfer ProteinHcertCollagen Type Iv Alpha-3-Binding ProteinGoodpasture Antigen-Binding ProteinGpbpStart Domain-Containing Protein 11Stard11Star-Related Lipid Transfer Protein 11 |
| Database Links | Reactome: R-HSA-1660661 Q9Y5P4-2 |
| Cellular Localisation | CytoplasmGolgi ApparatusEndoplasmic ReticulumPreferentially Localized To The Golgi Apparatus |
| Alternative Protein Names | Ceramide Transfer Protein proteinHcert proteinCollagen Type Iv Alpha-3-Binding Protein proteinGoodpasture Antigen-Binding Protein proteinGpbp proteinStart Domain-Containing Protein 11 proteinStard11 proteinStar-Related Lipid Transfer Protein 11 proteinCERT1 proteinCERT proteinCOL4A3BP proteinSTARD11 protein |
Information sourced from Uniprot.org