Human CEACAM6/CD66c protein (Recombinant) (C-His&Avi) (STJP019884)

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STJP019884
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Covered by St John's Laboratory Guarantee

Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation: Unconjugated
Formulation: Lyophilised from 0.22 Mu m filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 1 EU/Mu g of the protein by LAL method.
Gene Symbol: CEACAM6
Gene ID: 4680
Uniprot ID: CEAM6_HUMAN
Immunogen Region: Lys35-Gly320
Immunogen: Recombinant Human CEACAM6/CD66c Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Lys35-Gly320) of Human CEACAM6/CD66c (Accession #P40199) fused with a C-His&Avi tag at the C-terminus.
Immunogen Sequence: KLTIESTPFNVAEGKEVLLL AHNLPQNRIGYSWYKGERVD GNSLIVGYVIGTQQATPGPA YSGRETIYPNASLLIQNVTQ NDTGFYTLQVIKSDLVNEEA TGQFHVYPELPKPSISSNNS NPVEDKDAVAFTCEPEVQNT TYLWWVNGQSLPVSPRLQLS NGNMTLTLLSVKRNDAGSYE CEIQNPASANRSDPVTLNVL YGPDVPTISPSKANYRPGEN LNLSCHAASNPPAQYSWFI
Tissue Specificity Expressed in neutrophils. Expressed in columnar epithelial and goblet cells of the colon. Expressed in numerous tumor cell lines (at protein level).
Post Translational Modifications Glycosylated.
Function Cell surface glycoprotein that plays a role in cell adhesion and tumor progression. Intercellular adhesion occurs in a calcium- and fibronectin-independent manner. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8. Heterophilic interaction with CEACAM8 occurs in activated neutrophils. Plays a role in neutrophil adhesion to cytokine-activated endothelial cells. Plays a role in cell migration and cell adhesion to endothelial cells.
Protein Name Cell Adhesion Molecule Ceacam6
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6
Cea Cell Adhesion Molecule 6
Non-Specific Crossreacting Antigen
Normal Cross-Reacting Antigen
Cd Antigen Cd66c
Database Links Reactome: R-HSA-1566977
Reactome: R-HSA-202733
Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Apical Cell Membrane
Cell Surface
Localized To The Apical Glycocalyx Surface
Alternative Protein Names Cell Adhesion Molecule Ceacam6 protein
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 protein
Cea Cell Adhesion Molecule 6 protein
Non-Specific Crossreacting Antigen protein
Normal Cross-Reacting Antigen protein
Cd Antigen Cd66c protein
CEACAM6 protein
NCA protein

Information sourced from Uniprot.org

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