Human CEACAM6/CD66c protein (Recombinant) (C-His&Avi) (STJP019884)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human CEACAM6/CD66c Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Lys35-Gly320) of Human CEACAM6/CD66c (Accession #P40199) fused with a C-His&Avi tag at the C-terminus.
General Information
| Short Description | Recombinant-Human CEACAM6/CD66c-C-His&Avi protein was developed in hek293 cells using the region Lys35-Gly320. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from 0.22 Mu m filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | CEACAM6 |
| Gene ID | 4680 |
| Uniprot ID | CEAM6_HUMAN |
| Immunogen | Recombinant Human CEACAM6/CD66c Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Lys35-Gly320) of Human CEACAM6/CD66c (Accession #P40199) fused with a C-His&Avi tag at the C-terminus. |
| Immunogen Region | Lys35-Gly320 |
| Immunogen Sequence | KLTIESTPFNVAEGKEVLLL AHNLPQNRIGYSWYKGERVD GNSLIVGYVIGTQQATPGPA YSGRETIYPNASLLIQNVTQ NDTGFYTLQVIKSDLVNEEA TGQFHVYPELPKPSISSNNS NPVEDKDAVAFTCEPEVQNT TYLWWVNGQSLPVSPRLQLS NGNMTLTLLSVKRNDAGSYE CEIQNPASANRSDPVTLNVL YGPDVPTISPSKANYRPGEN LNLSCHAASNPPAQYSWFI |
Additional Info
| Tissue Specificity | Expressed in neutrophils. Expressed in columnar epithelial and goblet cells of the colon. Expressed in numerous tumor cell lines (at protein level). |
| Post Translational Modifications | Glycosylated. |
| Function | Cell surface glycoprotein that plays a role in cell adhesion and tumor progression. Intercellular adhesion occurs in a calcium- and fibronectin-independent manner. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8. Heterophilic interaction with CEACAM8 occurs in activated neutrophils. Plays a role in neutrophil adhesion to cytokine-activated endothelial cells. Plays a role in cell migration and cell adhesion to endothelial cells. |
| Protein Name | Cell Adhesion Molecule Ceacam6Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6Cea Cell Adhesion Molecule 6Non-Specific Crossreacting AntigenNormal Cross-Reacting AntigenCd Antigen Cd66c |
| Database Links | Reactome: R-HSA-1566977Reactome: R-HSA-202733Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorApical Cell MembraneCell SurfaceLocalized To The Apical Glycocalyx Surface |
| Alternative Protein Names | Cell Adhesion Molecule Ceacam6 proteinCarcinoembryonic Antigen-Related Cell Adhesion Molecule 6 proteinCea Cell Adhesion Molecule 6 proteinNon-Specific Crossreacting Antigen proteinNormal Cross-Reacting Antigen proteinCd Antigen Cd66c proteinCEACAM6 proteinNCA protein |
Information sourced from Uniprot.org