| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 12.6pg/mL |
| Detection Limit: | 31.2-2000pg/mL |
| Short Description: | This CDK16 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates, cell lysates or other biological fluids.. |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
| Gene Symbol: | CDK16 |
| Gene ID: | 5127 |
| Uniprot ID: | CDK16_HUMAN |
| Sample Type: | tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | Detected in pancreas islets (at protein level). Detected in brain and pancreas. |
| Post Translational Modifications | Phosphorylation of CDK16 is essential for the binding of CCNY, but also essential for the regulation of CDK16 kinase activity. Phosphorylation of CDK16 is essential for the binding of CCNYl1, but also essential for the regulation of CDK16 kinase activity. Ser-146 and Ser-153 are the most critical sites for the binding of CCNYL1 and for modulating CDK16 kinase activity. Phosphorylation at Ser-153 inhibits kinase activity. |
| Function | Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development. Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). |
| Protein Name | Cyclin-Dependent Kinase 16 Cell Division Protein Kinase 16 Pctaire-Motif Protein Kinase 1 Serine/Threonine-Protein Kinase Pctaire-1 |
| Database Links | |
| Cellular Localisation | Cytoplasm Cytoplasmic Vesicle Secretory Vesicle Cell Membrane Peripheral Membrane Protein Cytoplasmic Side Synapse Synaptosome Colocalizes With Insulin In Pancreas Islets Recruited To The Cell Membrane By Ccny |
| Alternative ELISA Names | Cyclin-Dependent Kinase 16 ELISA kit Cell Division Protein Kinase 16 ELISA kit Pctaire-Motif Protein Kinase 1 ELISA kit Serine/Threonine-Protein Kinase Pctaire-1 ELISA kit CDK16 ELISA kit PCTAIRE1 ELISA kit PCTK1 ELISA kit |
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Information sourced from Uniprot.org
