Name: Human CD83 protein (Recombinant) (C-His) (STJP001083)
SKU: STJP001083
Availability: InStock

Human CD83 protein (Recombinant) (C-His) (STJP001083)

SKU:

STJP001083

€90.63 - €280.63

Host:	HEK293 cells
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Conjugation:	Unconjugated
Formulation:	Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method:	< 0.1 EU/Mu g of the protein by LAL method.

Gene Symbol:	CD83
Gene ID:	9308
Uniprot ID:	CD83_HUMAN
Immunogen Region:	Thr20-Ala143
Immunogen:	Recombinant Human CD83 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Thr20-Ala143) of human CD83 (Accession #NP_004224.1) fused with a 6×His tag at the C-terminus.
Immunogen Sequence:	TPEVKVACSEDVDLPCTAPW DPQVPYTVSWVKLLEGGEER METPQEDHLRGQHYHQKGQN GSFDAPNERPYSLKIRNTTS CNSGTYRCTLQDPDGQRNLS GKVILRVTGCPAQRKEETFK KYRA

Tissue Specificity	Expressed by activated lymphocytes, Langerhans cells and activatd dendritic cells.
Post Translational Modifications	Glycosylated when expressed on activated dendritic cells.
Function	Transmembrane glycoprotein predominantly found on the surface of many immune cells including dendritic cells or lymphocytes that plays various roles in immune response regulation. Plays an essential role in CD4(+) T-selection, differentiation and stability by regulating the activity of the major E3 ubiquitin ligase responsible for controlling MHCII trafficking MARCHF8. Also inhibits MARCHF1 association with MHCII or CD86 to prevent their ubiquitination and subsequent degradation. In addition, acts as an important modulator of protective responses against acute infections.
Protein Name	Cd83 Antigen Hcd83 B-Cell Activation Protein Cell Surface Protein Hb15 Cd Antigen Cd83
Database Links
Cellular Localisation	Membrane Single-Pass Type I Membrane Protein
Alternative Protein Names	Cd83 Antigen protein Hcd83 protein B-Cell Activation Protein protein Cell Surface Protein Hb15 protein Cd Antigen Cd83 protein CD83 protein

Information sourced from Uniprot.org

Model	Name	Host
STJP005120	Human CD83 protein (Recombinant) (C-His) (STJP005120)	Mammalian Cells
STJP012060	Human CD83 protein (Recombinant-Active) (C-His) (STJP012060)	Mammalian Cells
STJP002780	Mouse CD83 protein (Recombinant) (C-His) (STJP002780)	HEK293 cells
STJP009775	Mouse CD83 protein (Recombinant) (N-GST & C-His) (STJP009775)	E. coli
STJP005327	Human MSLN protein (Recombinant) (C-His) (STJP005327)	Mammalian Cells

Human CD83 protein (Recombinant) (C-His) (STJP001083)

General Information